Manufacturer
Elanco, France
Composition
Complex preparation containing as active substances milbemycin oxime and praziquantel and excipients. It is available as tablet for kittens and young cats with 4 mg of milbemycin oxime and 10 mg of praziquantel per tablet and as tablet for adult cats with 16 mg of milbemycin oxime and 40 mg of praziquantel per tablet.
Pharmacological action
Milbemitsina oxime and praziquantel exhibit synergistic action and in combination have a broad spectrum of action against larval and mature forms of nematodes and cestodes. Milbemicina oxime included in the drug belongs to the group of macrocyclic lactones released as a result of enzymatic activity of Streptomyces hygroscopicus var. Aureolacrimosus. Milbemicina oxime is active against nematodes parasitizing in the gastrointestinal tract of cats, as well as nematode larvae Dirofilaria immitis. The mechanism of action of milbemicin is due to increased permeability of cell membranes for chlorine ions, which leads to overpolarization of membranes of nervous and muscular tissue cells, paralysis and death of the parasite. Maximum concentration of milbemycin oxime in blood plasma is reached after 2 hours. The compound is eliminated from the body mainly unchanged, the half-life is about 13 hours after oral administration of the drug. Praziquantel is an acylated derivative of pyrazine isoquinoline and has a pronounced effect against cestodes and nematodes. Increasing permeability of cell membranes of the parasite for calcium ions, causes depolarization of membranes, contraction of muscles and destruction of tegument, which leads to death of the parasite and promotes its elimination from the animal body. Maximum concentration of praziquantel in blood plasma is reached after 1 hour. The compound is eliminated from the body mainly in the form of inactive metabolites with urine, the elimination half-life is about 3 hours after oral administration of the drug. Milbemax belongs to the group of compounds moderately dangerous for warm-blooded animals; in recommended doses it has no sensitizing, embryotoxic and teratogenic effects. It is well tolerated by cats of different breeds and ages. The drug is toxic to fish and other hydrobionts.
Indications
Appointed with prophylactic and therapeutic purpose for deworming cats with nematode diseases (toxocariasis, ankylostomiasis) and cestode diseases (echinococcosis, dipilidiosis, teniasis).
Contraindications
Increased individual sensitivity to the drug. Prescription of milbemax in cats under six weeks of age, cats in the first two-thirds of pregnancy, as well as ill with infectious diseases and convalescing animals is prohibited. It is not recommended to use in cats weighing less than 0.5 kg. Do not use in cats with kidney and liver dysfunction.
Side effects
Animals hypersensitive to components milbemax possible allergic reactions. With proper use and dosage side effects are usually not observed. At overdose in some cats may experience tremors, symptoms of which spontaneously disappear within 24 hours and do not require the use of drugs.
Dosage and administration
Milbemax is administered orally to cats once daily in the morning feeding with small amount of feed or administered by force on the tongue after feeding at a minimum therapeutic dose of 2 mg milbemycin oxime and 5 mg praziquantel per 1 kg of animal weight.
Conditions of storage
With list B caution. In a dry, dark place out of reach of children and animals at 5 to 25 ° C.
Shelf life
2 years. Shelf life after opening the blister - 6 months.
Active ingredient
Milbemicina oxime, praziquantel.
Dosage form
tablets
Indications
Against helminths