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Exoderil 1% external solution 20ml
Exoderil 1% external solution 20ml
Product Code: 20817 exoderil-sandoz

Exoderil 1% external solution 20ml

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    1 ml of the solution contains:
    Active ingredient: naphthyphine hydrochloride - 10 mg;
    auxiliary substances: propylene glycol - 50 mg, ethanol - 400 mg, purified water - 475 mg.

Pharmacotherapeutic group

    antifungal agent

Pharmacodynamics .

    Naphtifine is an antifungal agent for external use, belonging to allilamines class. The mechanism of action is related to inhibition of squalene-2,3-epoxidase, which results in reduction of formation of ergosterol, a component of the cell wall of the fungus. Active against dermatophytes such as Trichophyton, Epidermophyton and Microsporum, moulds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii). Against dermatophytes and aspergillus naphthifene is fungicidal. It has fungicidal or fungistatic activity against yeast fungi depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms, which may cause secondary bacterial infections. It has anti-inflammatory properties, which help to quickly resolve symptoms of inflammation, especially itching.


    Naphtifine rapidly penetrates into the skin, forming stable antifungal concentrations in various layers, making it suitable for once-daily use.


    - Fungal infections of the skin and skin folds (tinea corporis, tinea inguinalis), including interfinger mycoses (tinea manum, tinea pedum);
    - fungal infections of the nails (onychomycoses);
    - skin candidiasis;
    - pityriasis;
    - dermatomycoses (with or without associated itching).
    Exoderil® is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis and hair growth areas.


    Hypersensitivity to naphthyphine or propylene glycol; pregnancy and lactation (safety and efficacy not determined). Application to the wound surface is contraindicated.
    With caution:
    Childhood (clinical experience limited).
    Pregnancy and lactation:

Dosage and administration.

    Exoderil® is applied 1 time daily to the affected skin surface and its neighbouring areas (about 1 cm of healthy skin edge) after thorough cleaning and drying. Duration of therapy with dermatomycosis - 2-4 weeks (if necessary - up to 8 weeks), with candidiasis - 4 weeks.
    In case of nail lesions Exoderil® is applied 2 times a day to the affected nail. Before the first use of the drug, remove the affected part of the nail with scissors or a nail file as much as possible. Duration of therapy for onychomycosis is up to 6 months.
    In order to prevent relapse, treatment should be continued for at least 2 weeks after disappearance of clinical symptoms.

Side effects

    Local reactions such as dry skin, skin hyperemia and burning may occur in individual cases. The side effects are reversible and do not require cancellation of the treatment.


    No cases of overdose have been reported.

Drug interaction

    No interaction with other drugs has been reported.


    Precautions for use:
    Exoderil® is not intended for use in ophthalmology. Avoid contact of the drug with the eyes.
    Effect on the ability to drive vehicles and other mechanisms:
    Exoderil® has no adverse effect on the ability to drive vehicles and perform other activities requiring concentration and quick psychomotor reactions.

Storage temperature

    2℃ to 25℃
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