Manufacturer
Mosagrogen, Russia
Composition
Gentamitsin sulfate 4% as an active ingredient in 1 ml contains gentamitsin sulfate (recalculated to the base) - 40 mg, and as additives: trilon B - 0.1 mg, sodium pyrosulfate - 3.2 mg, and also water for injection up to 1 ml.
Pharmacological action
Gentamicin has a broad spectrum of antimicrobial action; it is active against majority of Gram-negative and Gram-positive microorganisms, including Proteus, Escherichia, Salmonella and Staphylococcus aureus. The antibiotic has no effect on anaerobic bacteria, fungi and viruses. When administered intramuscularly, the drug penetrates well into many organs and tissues. Maximum concentration in blood is reached 1 hour after injection. After a single injection the therapeutic concentration of the antibiotic in the body is maintained for 8-12 hours. When administered orally the drug is practically not absorbed from the gastrointestinal tract and exerts its effect only in the intestine for 12 hours. When parenteral administration gentamicin is excreted unchanged mainly with urine, and when administered orally - with feces. According to State Standard 12.1.007-76 gentamicin sulfate 4% solution is classified as Class 4 Hazardous substance.
Contraindications
Impaired renal function, simultaneous use with other nephrotoxic drugs, simultaneous use with muscle relaxants and some general anesthetics (Chalaton), hypersensitivity to gentamicin, pregnancy. Gentamicin should not be used concomitantly with penicillins, some cephalosporins, other aminoglycoside antibiotics, chloramphenicol, colistin, polymyxin, sulfonamides.
Side effects
Allergic reactions (skin rash, itching, fever). Prolonged use of the drug may cause dysfunction of the eighth cerebral nerve (dogs, cats), it may also have adverse effects on the fetus (dysfunction of the kidneys and the eighth cerebral nerve).
Directions for use and dosages
Gentamicin 4% solution for injection is administered intramuscularly at the following dosage: Cattle, small ruminants, horses and pigs: 0.5 ml of solution per 10 kg body weight twice a day (2 mg DV per kg body weight twice a day). Dogs and cats: First day - 1.1 ml of the solution per 10 kg body weight twice a day (4.4 mg DV per kg body weight twice a day); subsequent days - 1.1 ml of the solution per 10 kg body weight once a day. Newborn animals during the first days of life are given only half of the recommended dose. The course of treatment shall be 3-5 days. Gentamicin 4% solution for injection must not be mixed with other drugs in one syringe.
Special precautions
Slaughter of animals for meat shall be allowed not earlier than 45 days after discontinuation of the drug. Meat of animals slaughtered before expiry of specified period can be used as feed for fur animals or for production of meat and bone meal. Milk obtained from animals to which gentamicin 4% solution for injection was used shall not be used for human consumption within 3 days after discontinuation of the drug. Such milk may be used for feeding animals.
Active ingredient
Gentamicin
Dosage form
solution for injection
Volume
100 ml
Form of production
Solution
