Human leukocyte interferon N10 vials
Active substance
Interferon alfa
Amount in a package
10
Dosage form
intranasal solution
Manufacturer
Microgen NGO, Russia
Composition
Active substance: interferon alfa
pharmachologic effect
Interferon leukocytic human is a mixture of various subtypes of natural interferon alpha from human blood leukocytes. Has antiviral, antiproliferative, immunomodulating and antitumor effect. The mechanism of antiviral action is to create protective mechanisms in virus-free cells: a change in the properties of cell membranes that prevent the virus from entering the cell; initiation of the synthesis of a number of specific enzymes that prevent the replication of viral RNA and the synthesis of proteins of the virus. The antiproliferative effect is due to direct mechanisms that cause changes in the cytoskeleton and cell membrane that regulate the processes of differentiation and cellular metabolism, which in turn inhibit the proliferation of cells, especially tumor cells. It modulates the expression of some oncogenes (myc, sys, ras), which allows to "normalize" the neoplastic transformation of cells and thereby inhibit tumor growth. Immunomodulating effect is caused by stimulation of activity of macrophages and natural killer cells (macrophages are involved in the process of antigen presentation to immunocompetent cells, and natural killer cells participate in the immune response of the organism to tumor cells).
Indications
Hairy cell leukemia, chronic myelogenous leukemia, viral hepatitis B, viral active hepatitis C, primary (essential) and secondary thrombocytosis, transitional form of chronic granulocyte leukemia and myelofibrosis, multiple myeloma, kidney cancer; AIDS related Kaposi's sarcoma, mushroom mycosis, reticulosarcoma, multiple sclerosis, prevention and treatment of influenza and acute respiratory viral infection.
Contraindications
Hypersensitivity, severe heart disease (including history), acute myocardial infarction, expressed violations of the liver, kidney or hematopoiesis system, epilepsy and / or other disorders of the central nervous system;
chronic hepatitis against decompensated liver cirrhosis;
chronic hepatitis in patients receiving or shortly before receiving immunosuppressant therapy (except for short-term pre-treatment with steroids).
Pregnancy, breast-feeding (should stop breastfeeding), children's age.
Side effects
Lethargy, fever, chills, loss of appetite, muscle pain, headache, joint pain, sweating, nausea, vomiting, taste changes, dry mouth, weight loss, diarrhea, abdominal pain, constipation, flatulence, increased peristalsis, heartburn, liver dysfunction, hepatitis, dizziness, visual disturbances, ischemic retinopathy, depression, drowsiness, impaired consciousness, nervousness, sleep disturbance, skin allergic reactions (rash, itching).
How to take, intake and dosage
The dose, frequency and duration of use are determined depending on the indications, the severity of the disease, the mode of administration, the individual reaction of the patient.
Special instructions
The interferon solution should be prepared immediately before use. In the process of treatment with Interferon, leukocyte human dry requires systematic monitoring of blood and liver pattern. If you have flu symptoms, take paracetamol.
Form of issue
Injection
