The drug is a filtrate of phagolysate, active against staphylococcal bacteria of the most common phage types, including Staphylococcus aureus.
Staphylococcal bacteriophage - immunobiological preparation, phage.
Staphylococcal bacteriophage has the ability to specifically lyse staphylococcal bacteria isolated from purulent infections, including Staphylococcus aureus.
Staphylococcus bacteriophage is used to treat and prevent purulent infections of the skin, mucous membranes, visceral organs caused by staphylococcal bacteria, as well as in dysbacteriosis:
- diseases of the ear, throat, nose, respiratory system and lungs (sinusitis, otitis media, tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy);
- surgical infections (purulent wounds, infected burns, abscess, phlegmon, furuncle, carbuncle, hydradenitis, panaritium, infiltrated and abstained staphylococcal sycosis, paraproctitis, mastitis, bursitis, tendovaginitis, osteomyelitis);
- urogenital pathology (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis);
- enteral pathology (gastroenterocolitis, cholecystitis, intestinal dysbiosis);
- generalized septic diseases;
- purulent-inflammatory diseases of the newborn (omphalitis, gastroenterocolitis, sepsis);
- other diseases of staphylococcal etilogy;
- prevention of purulent processes in newly infected wounds (abdominal and chest cavity surgery, street and industrial injuries, etc.); for the prevention of nosocomial infections according to epidemic indications.
Reactions to the introduction of staphylococcal bacteriophage have not been established.
With intradermal administration, there may be rapidly passing reversible redness and inflammation.
The use of staphylococcal bacteriophage does not preclude the use of other drugs.
You can make a combined treatment of staphylococcal bacteriophage in combination with antibiotics.
How to take, the course of administration and dosage
An important condition for effective phage therapy is a preliminary determination of the pathogen sensitivity of the pathogen (determination of sensitivity to staphylococcal bacteriophage strains isolated from the patient).
Staphylococcal bacteriophage is injected into the site of infection. Duration of treatment is 5-15 days. Doses and route of administration depend on the nature of the source of infection (locally in the form of irrigation, lotions and plugging; intracutaneously; in the cavity - abdominal, pleural, articular; into the bladder through the catheter; per os and per rectum). In case of recurrent course of the disease, repeated courses of treatment are possible.
Locally in the form of irrigation, lotions and plugging with liquid phage in an amount up to 200 ml, taking into account the size of the affected area, or smearing with ointment.
Treatment of inflammatory diseases with localized lesions, it is advisable to carry out simultaneously both locally and through the mouth for 7-20 days.
In case of purulent-inflammatory diseases of the ear, throat, and nose, the staphylococcal bacteriophage is administered in a dose of 2-10 ml, 1-3 times a day; used for rinsing, washing, instillation, the introduction of moistened turund (leaving them for 1 hour).
With boils and carbuncles, liquid staphylococcal bacteriophage is injected directly into the center or under the base of the infiltrate, as well as around it. Injections are made daily, every other day, depending on the reaction, in successively increasing doses: for 1 injection, 0.5 ml, then 1 - 1.5 - 2 ml. A total of 3-5 injections per treatment cycle.
In case of abscesses, staphylococcal bacteriophage is injected into the cavity of the focus after puncture removal of pus. The amount of drug injected should be somewhat less than the volume of removed pus. At the opening of an abscess, a tampon is introduced into the cavity, which is abundantly moistened with a staphylococcal bacteriophage.
In chronic osteomyelitis, the staphylococcal bacteriophage is infused into the wound immediately after its surgical treatment.
For the treatment of deep forms of pyodermatitis, staphylococcal bacteriophage is used intracutaneously in small doses of 0.1-0.5 ml in one place or, if necessary, up to 2 ml in several places. Only 10 injections every 24 hours.
Introduction to the cavity - abdominal, pleural, articular and other up to 100 ml of bacteriophage. Capillary drainage is left through which the bacteriophage is reintroduced every other day, only 3-4 times.
With cystitis, a staphylococcal bacteriophage is injected into the cavity of the bladder using a catheter.
For purulent pleurisy, bursitis or arthritis, staphylococcal bacteriophage is injected into the cavity after removing pus from it in an amount up to 20 ml. and more, every other day, 3-4 times.
Inside in the form of tablets, staphylococcal bacteriophage is used to treat urogenital infectious diseases - cystitis, pyelitis, pyelonephritis, endometritis, salpingoophoritis, enteric infections and other diseases caused by staphylococcal bacteria.
In intestinal forms of the disease caused by staphylococcus and intestinal dysbiosis, liquid staphylococcal bacteriophage is used: orally 3 times a day on an empty stomach 1.5-2 hours before a meal; rectally - once a day (liquid in the form of enemas or suppositories). When intestinal dysbiosis treatment is carried out for 7-10 days under bacteriological control. In children of the first days of life, in the first two doses, staphylococcal bacteriophage is diluted 2 times with boiled water. In the absence of side reactions (regurgitation, rash on the skin), then undiluted preparation is used. In this case, it can be mixed with breast milk.
In sepsis, enterocolitis of newborns, including premature babies, staphylococcal bacteriophage is used in the form of high enemas (through a vapor tube or catheter) 2-3 times a day. Perhaps a combination of rectal (enema) and oral (through the mouth) use of the drug.
In the treatment of omphalitis, pyoderma, infected wounds in newborns, the Staphylococcus bacteriophage is used in the form of applications twice daily (a gauze cloth is moistened with a Staphylococcus bacteriophage and applied to the umbilical wound or the affected skin).
Staphylococcal bacteriophage is used for prophylaxis in the amount of 50 ml. for irrigation of postoperative wounds, etc.
In order to prevent sepsis and enterocolitis in newborns with intrauterine infection or the risk of nosocomial infection, staphylococcal bacteriophage is used as an enema 2 times a day for 5-7 days.
Recommended dosage of Staphylococcus bacteriophage:
|PATIENT AGE||DOSE FOR 1 RECEPTION (ml)|
in an enema
|from 1 year to 3 years ||15||20-30|
|from 3 to 8 years ||15-20||30-40|
|from 8 years and older||20-30|
Staphylococcal bacteriophage liquid is not suitable for use in cloudiness and the presence of flakes.
Store in a dry, dark place at a temperature of 2-8 ° C.