Uses of Concor 5mg Tab:
Side Effects of Concor 5mg Tab:
Bradycardia, Worsening Of Pre-Existing Heart Failure, Hypotension, Dizziness, Headache, GI Disturbances (E.G. Nausea, Vomiting, Diarrhoea, Constipation), Cold Or Numb Extremities, Asthenia, Fatigue, Upper Resp Infection, Rhinitis, Sinusitis, Dyspnoea.
Drug Interactions of Concor 5mg Tab:
May Potentiate AV Conduction Time And May Increase Negative Inotropic Effect W/ Class I Antiarrhythmic Drugs (E.G. Quinidine, Disopyramide, Propafenone). Concomitant Catecholamine-Depleting Drugs (E.G. Reserpine, Guanethidine) May Produce Excessive Sympathetic Activity. May Exacerbate Rebound HTN Upon Discontinuance Of Clonidine Treatment. Increased Risk Of Bradycardia W/ Digitalis Glycosides. Reduced Hypotensive Effect W/ NSAIDs.
Contraindications of Concor 5mg Tab:
Cardiogenic Shock, Overt Cardiac Failure, 2nd Or 3rd Degree AV Block, SA Block, Sick Sinus Syndrome, Symptomatic Bradycardia And Hypotension, Untreated Phaeochromocytoma, Metabolic Acidosis, Severe, Peripheral Arterial Disease, Severe Bronchial Asthma Or Severe COPD.
Mechanism of Action of Concor 5mg Tab:
Bisoprolol Selectively And Competitively Blocks Β1-Receptors But Has Little Or No Effect On Β2-Receptors Except At High Doses. Onset: 1-2 Hr. Absorption: Absorbed Almost Completely From The GI Tract. Bioavailability: Approx 90%. Time To Peak Plasma Concentration: 2-4 Hr. Distribution: Volume Of Distribution: 3.5 L/Kg. Plasma Protein Binding: Approx 30%. Metabolism: Undergoes Minimal First-Pass Metabolism. Excretion: Via Urine (Approx 50% As Unchanged Drug And 50% As Metabolites). Plasma Elimination Half-Life: 10-12 Hr.
Special Precautions for Concor 5mg Tab:
Patients W/ Compensated Heart Failure, Bronchospastic Disease, Myasthenia Gravis, DM. Patients Undergoing Major Surgery Involving General Anaesth. May Mask Signs And Symptoms Of Hypoglycaemia And Hyperthyroidism. Avoid Abrupt Withdrawal As It May Exacerbate Angina, MI And Ventricular Arrhythmias Or May Precipitate Thyroid Storm. Renal And Hepatic Impairment. Pregnancy And Lactation. Monitoring Parameters Monitor ECG, Heart Rate And BP. Regularly Monitor Blood Glucose In Patients W/ DM.