Mometasone, Salicylic acid
Amount in a package
1 g of ointment contains:
active ingredients: mometasone furoate 1 mg, salicylic acid 50 mg;
auxiliary substances: hexylene glycol, purified water, propylene glycol stearate, white wax, white petrolatum.
Elocom S - combined preparation with anti-inflammatory and keratolytic action.
Mometasone furoate - GCS. It has anti-inflammatory, antipruritic and vasoconstrictive properties. In general, the mechanism of anti-inflammatory action of GCS of topical application is unclear. It is believed that SCS induces the release of proteins that inhibit phospholipase A2 and are known under the general name lipocortins. It is believed that these proteins control the biosynthesis of such potent inflammatory mediators as PG and LT by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
In experiments in vitro, it was shown that mometasone furoate is a potent inhibitor of the synthesis of 3 cytokines involved in the development of the inflammatory process and its maintenance - IL-1, IL-6 and tumor necrosis factor α-factor (TNF-alpha). Salicylic acid causes exfoliation of the stratum corneum.
After a single local application of the ointment, approximately 1.5% of the applied dose is subjected to systemic absorption. The drug, which enters the systemic circulation, is excreted in the urine and feces.
Removal of inflammatory manifestations and hyperkeratosis in psoriasis; atopic and seborrheic dermatitis.
Application in pregnancy and lactation
Controlled studies of the use of the drug during pregnancy were not conducted. Ointment Elocom C can be used in pregnant women only on condition that the expected benefit of the treatment justifies the possible risk to the fetus.
The information that local application of GCS or salicylic acid can lead to systemic action and the detection of the drug in breast milk is not available. Since many drugs are excreted in breast milk, caution should be exercised when administering Elocom ointment with nursing women.
- hypersensitivity to mometasone furoate, salicylic acid and other components of the drug;
- children's age (up to 12 years);
- bacterial, viral (simple herpes, chicken pox, shingles), fungal skin infections;
- perioral dermatitis;
- postvaccinal reactions;
- Weak or moderate burning sensation at the site of ointment application,
- skin atrophy,
- maceration of the skin,
- dry skin,
- perioral dermatitis,
- allergic contact dermatitis,
- the appearance of atrophic bands of the skin,
- prickly heat,
- secondary infections,
- In children, in addition, suppression of the function of the hypothalamic-pituitary-adrenal system is possible, incl. with the development of Cushing's syndrome.
With local application of the ointment, small amounts of salicylates in the blood plasma were noted. According to data on the interaction of salicylates with other substances after ingestion or application to the skin, it is possible to change the effect of the following medicinal compounds: tolbutamide (butamid), methotrexate, heparin, pyrazinamide, agents that promote the excretion of uric acid and preparations of coumarin type. Other GCS and ammonium sulfate may affect the salicylic acid content. These interactions should be borne in mind when applying Elocom C ointment together with these compounds.
How to take, intake and dosage
Ointment Elocom S should be applied to the affected skin 2 times / day (morning and evening).
The maximum daily dose is 15 g.