Assign 1-2 drops to the conjunctival sac 3 times / day.
When using the bottle for the first time, turn the bottle cap while pressing down and then open the bottle.
Eye drops in the form of a transparent red solution.
cytochrome C 0.675 mg
adenosine 2 mg
nicotinamide 20 mg
Excipients: benzalkonium chloride - 0.04 mg, sodium succinate hexahydrate - 1 mg, sorbitol - 10 mg, sodium dihydrogen phosphate dihydrate - 4.415 mg, sodium hydrogen phosphate dihydrate - 2.847 mg, water d / i - up to 1 ml.
Children and adolescents up to 18 years of age (due to the lack of data on the efficacy and safety of the drug in children and adolescents);
hypersensitivity to the components of the drug.
Combined drug that improves the energy metabolism of the lens. Cytochrome C plays an important role in the biochemical redox processes in the tissues of the eyeball and is an antioxidant. Adenosine, a precursor of ATP, takes part in the metabolic processes of the lens. Nicotinamide stimulates the synthesis of nicotinamide dinucleotide, a cofactor of dehydrogenases.
Absorption and distribution
When applied topically, cytochrome C is not absorbed into the systemic circulation. Adenosine penetrates well through the cornea.
Metabolism and excretion
Cytochrome C is completely metabolized in the body in the same ways as amino acids, and heme is broken down to bilirubin, which is excreted in the bile. Adenosine is metabolized in almost all tissues with the formation of inosine, xanthine and urate, which are excreted in the urine. Ribose, which is part of the adenosine molecule, is metabolized to glyceraldehyde-3-phosphate, and then to pyruvate, and finally degraded in the Krebs cycle. T1 / 2 of adenosine from plasma is less than 1 min. Nicotinamide is partially metabolized to nicotinic acid. Both compounds are methylated to form N-methylnicotinamide, which is further broken down in the liver. Unchanged nicotinamide and metabolites are excreted in the urine.
From the side of the organ of vision: short-term burning sensation and tingling of the eyes, allergic conjunctivitis, contact dermatitis. Systemic reactions: extremely rarely - short-term nausea, arterial hypotension, dizziness, shortness of breath; feeling of heat and pulsation in the temples, fainting (due to the vasodilating effect of niacin).
Application during pregnancy and lactation
There is not enough experience with the use of the drug OftanЃ Katakhrom during pregnancy and lactation (breastfeeding). It is possible to use the drug OftanЃ Katakhrom during pregnancy and lactation as directed by a doctor and in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus or infant.
Application in children
Contraindicated in children and adolescents under 18 years of age (due to the lack of data on the efficacy and safety of the drug in children and adolescents).
During the period of treatment with OftanЃ Katahrom, you should not wear soft contact lenses, because the preservative can be deposited in them and have an adverse effect on the tissues of the eye. Before using OftanЃ Katachroma, contact lenses should be removed and reinstalled 15 minutes after instillation of the drug.
Influence on the ability to drive vehicles and use mechanisms
Patients who develop short-term eye irritation after instillation of the drug should avoid driving vehicles, working with machinery, machine tools or any other equipment that requires good visual acuity immediately after using the eye drops.
There is no data on an overdose of OftanЃ Katakhrom.
There was no clinically significant interaction of the drug OftanЃ Katahrom with other drugs.