Release form
Tablets
Pharmacological action
Detralex® has venotonic and angioprotective properties.
The
drug reduces the extensibility of veins and venous congestion, reduces
the permeability of capillaries and increases their resistance. The
results of clinical studies confirm the pharmacological activity of the
drug in relation to venous hemodynamics.
The statistically
significant dose-dependent effect of Detralex® was demonstrated for the
following venous plethysmographic parameters: venous capacity, venous
extensibility, time of venous emptying. The optimal dose / effect ratio
is observed when taking 2 tablets.
Detralex® improves venous
tone: venous occlusion plethysmography has been shown to decrease venous
emptying time. In patients with signs of severe microcirculatory
dysfunction (statistically significant), compared with placebo, an
increase in capillary resistance, evaluated by angiostereometry, after
therapy with Detralex®, is noted.
The therapeutic efficacy of
Detralex® has been proven in the treatment of chronic lower extremity
vein diseases, as well as in the treatment of hemorrhoids.
Pharmacokinetics
The
main excretion of the drug occurs with feces. With urine, on average,
about 14% of the accepted amount of the drug is excreted.
T1 / 2 is 11 hours.
The drug undergoes active metabolism, as evidenced by the presence of phenolic acids in the urine.
Indications
Symptomatic
therapy of venous-lymphatic insufficiency, feeling of heaviness in the
legs, pain, Morning leg fatigue, cramps, trophic disorders, symptomatic
therapy of exacerbation of hemorrhoids.
Contraindications
Hypersensitivity to the components of the drug.
Pregnancy and lactation
Pregnancy
Animal experiments have not revealed teratogenic effects.
To date, there have been no reports of any side effects when using the drug in pregnant women.
Breastfeeding
Due to a lack of data regarding the excretion of the drug in breast milk, lactation is not recommended for women.
Special instructions
With
exacerbation of hemorrhoids, the use of this drug does not replace the
specific treatment of other anal disorders. The duration of treatment
should not exceed the recommended time frame. In the event that the
symptoms do not disappear after a short therapy, a proctological
examination should be carried out and the ongoing therapy should be
reviewed.
In the presence of impaired venous circulation, the
maximum treatment effect is ensured by a combination with a healthy,
well-balanced lifestyle, in which it is advisable to avoid long exposure
to the sun, reduce body weight, take walks and, in some cases, wear
special socks that improve blood circulation.
Effect on the ability to drive vehicles and control mechanisms
The drug does not affect the ability to drive vehicles and perform work requiring a high speed of psychomotor reactions.
Composition
1 tablet contains:
Active
ingredients: purified micronized flavonoid fraction 500 mg (including
diosmin (90%) 450 mg, flavonoids expressed as hesperidin (10%) 50 mg)
Excipients:
gelatin gelatin , microcrystalline cellulose, sodium starch glycolate,
talc, glycerol, macrogol 6000, hydroxypropyl methylcellulose, iron oxide
yellow (E172), iron oxide red (E172), titanium dioxide (E171), sodium
lauryl sulfate.
Dosage and administration of
The drug is taken orally.
The recommended dose is 2 tablets per day, 1 tablet in the middle of the day and 1 tablet in the evening during meals.
During an exacerbation of hemorrhoids - 6 tablets per day for 4 days, then 4 tablets per day for the next 3 days.
Side effects
From the central nervous system: rarely - dizziness, headache, general malaise.
From the gastrointestinal tract: often - diarrhea, dyspepsia, nausea, vomiting infrequently - colitis.
From
the skin: rarely - rash, itching, urticaria of unspecified frequency -
isolated swelling of the face, lips, eyelids. In exceptional cases,
angioedema.
Active ingredient
Hesperidin, Diosmin
Over-the-counter
Dosage form
tablet
Appointment
Adult doctor, Pregnant II and III trimester doctor, For women p6roduct5 lkp Adult doctor, Pregnant doctor
Indications
srdlkr1, Urinary tract infections, Urinary tract infections,
Pharyngitis, Osteomyelitis, Tonsillitis, Osteomyelitis, Skin infections,
Bronchitis, Sinusitis, Cholecystitis, Periodontitis, Otitis Patients
eye, Trophic ulcers, Hemorrhoids
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