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Galavit, rectal suppositories 100 mg 10 pcs
Galavit, rectal suppositories 100 mg 10 pcs
Product Code: galavit-rs-100-10

Galavit, rectal suppositories 100 mg 10 pcs

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$35.00
2-3 Days

Composition


Active ingredient:

aminodihydrophthalazindione sodium (Galavit®) - 100 mg;

excipients:

Vitepsol W-35 (fatty acids glycerides) - 575 mg,

Vitepsol H-15 (fatty acids glycerides) - 575 mg.
Pharmacological action

Pharmacotherapeutic group:

Immunomodulatory and anti-inflammatory agent.

ATX code: L03, G02.

Pharmacological properties:

Pharmacodynamics .


The mechanism of action of the drug is related to its ability to regulate

functional and metabolic activity of innate and adaptive immune cells (monocytes, macrophages, neutrophils, natural killers, etc.). Galavit normalizes phagocytic activity of monocytes/ macrophages, bactericidal activity of neutrophils and cytotoxic activity of NK-cells.

At the same time, restoring the reduced activity of innate and adaptive immunity cells, the drug increases the body's resistance to infectious diseases.

Moreover Galavit normalizes antibody formation, increases functional activity (affinity) of antibodies.

At inflammatory diseases the preparation reversibly for 6-8 hours inhibits excessive synthesis by overactivated macrophages of tumor necrosis factor-α, interleukin-1, interleukin-6 and other pro-inflammatory cytokines which level determines the degree of inflammatory reactions, their

cyclicity, as well as the severity of intoxication of the body. Galavit decreases the production of hyperactivated macrophages of reactive oxygen species, thus

thereby reducing the level of oxidative stress and protecting tissues and organs from the damaging effects of radicals.

Normalization of excessively high functional activity of phagocytic cells leads to restoration of their antigen-presenting and regulatory functions, reducing the level of autoaggression.

The drug has no allergizing, mutagenic, embryotoxic, teratogenic and carcinogenic effect.

Pharmacokinetics


It is mainly eliminated from the body via the kidneys. After rectal administration

elimination half-life is 40-60 minutes. The main pharmacological effects are observed within 72 hours. Aminodihydrophthalazindione sodium in suppositories with rectal administration has high bioavailability, due to which both local and expressed systemic action is achieved.


Indications


As an immunomodulatory and anti-inflammatory agent in the treatment of immunodeficiency disorders in adults and adolescents over 12 years of age:

- Infectious-inflammatory urogenital diseases (urethritis of chlamydial and trichomonadic etiology, chlamydial prostatitis, acute and chronic salpingo-oophoritis, endometritis);

- Purulent inflammatory diseases of the pelvic organs;

- Chronic recurrent diseases caused by the herpes virus;

- Diseases caused by the papilloma virus;

- Postoperative rehabilitation of patients with uterine myoma;

- Complications of postoperative period in women of reproductive age;

- Postoperative pyo-septic complications and their prevention (including cancer patients);

- Chronic recurrent furunculosis, rye;

- non-specific prevention and treatment of influenza and acute respiratory infections.

- inflammatory diseases of the mucous membranes of the mouth and throat,

periodontal disease;

- viral hepatitis;

- Infectious intestinal diseases accompanied by intoxication

and/or diarrhea;

- gastric and 12 duodenal ulcer;

- asthenic conditions, neurotic and somatoform disorders, decreased physical performance (including athletes); mental, behavioral and postabstinence disorders with alcohol and drug dependence.


Administration during pregnancy and lactation

The drug is contraindicated in pregnancy and during breast-feeding.

Contraindications .

Hypersensitivity to Galavit and other components of the drug, pregnancy and lactation, children under 12 years of age.

Side effects

In rare cases, allergic reactions are possible. If you notice any side effects mentioned in the instructions or if they worsen, or if you notice any other side effects not mentioned in the instructions, please inform your doctor.

Interactions

When concomitant use, it is possible to reduce the course doses of antibiotics. Cases of incompatibility with other drugs have not been reported.


How to take, the course of treatment and dosage


Rectally. The suppository is released from the contoured package and then inserted into the rectum. It is recommended to free the intestines beforehand.

The dose and duration of administration of the drug depends on the nature, severity and duration of the disease.

- In urogenital diseases - urethritis of chlamydial and trichomonadic aetiology, chlamydial prostatitis: 1 day 1 suppository twice and then one every other day. The course of 10-15 suppositories (depending on the severity of the pathological process).

- In salpingo-oophoritis, endometritis in the acute period: 2 days of 2 suppositories once a day, then one suppository at an interval of 72 hours. In the chronic period: 5 days with 1 suppository once a day, then one suppository every 72 hours. The course is 20 suppositories.

- In acute and chronic purulent diseases of the pelvic organs - in the acute period: 1 day 2 suppositories once, 3 days one suppository daily, then one every other day for 5 days. The course of 10 suppositories. In the chronic period: 5 days 1 suppository once daily, then one every 72 hours. The course of 20 suppositories.

- In chronic recurrent diseases caused by the herpes virus: 1 suppository daily 5 suppositories, then 1 suppository every other day - 15 suppositories.

- In diseases caused by the papilloma virus: 5 days 1 suppository 1 time a day, then 1 suppository every other day. The course of 20 suppositories.

- For the postoperative rehabilitation of patients with uterine myoma and complications of the postoperative period in women of childbearing age: 5 days 1 suppository once a day, then one suppository every other day. The course is 15 suppositories.

- For prevention and treatment of surgical complications in pre- and postoperative period (including cancer patients): Administration: 1 suppository 1 time per day. 5 suppositories before surgery, 5 suppositories after surgery, 1 every other day and 5 suppositories - at intervals of 72 hours. If the course of the disease is severe, the initial dose is 2 suppositories once or twice a day with one suppository. The course is 20 suppositories.

- In chronic recurrent furunculosis, rust: 5 days with one suppository once a day, then one suppository every other day. The course of 20 suppositories.

- For non-specific prevention and treatment of influenza and acute respiratory infections: one suppository 1 time a day. The course of 5 days.

- In inflammatory diseases of the mucous membranes of the mouth and throat, periodontal disease: The initial dose of 1 suppository daily - 5 suppositories, then one suppository at intervals of 72 hours. The course of 15 suppositories.

- In viral hepatitis: the initial dose is 2 suppositories once, then one suppository twice a day until relief of symptoms of intoxication and inflammation. Subsequent continuation of the course of 1 suppository at intervals of 72 hours. The course of 20 -25 suppositories.

- In acute infectious intestinal diseases accompanied by diarrheal syndrome: the initial dose is 2 suppositories once, then 1 suppository 2 times a day until relief of symptoms of intoxication. Further continuation of the course of 1 suppository at intervals of 72 hours is possible. The course of 20-25 suppositories.

- With gastric and 12 duodenal ulcers in the acute period: 2 days 2 suppositories once a day, then 1 suppository at an interval of 72 hours. The course of 15-25 suppositories. In the chronic period: 5 days, 1 suppository 1 time per day, then 1 suppository 72 hours apart. The course of 20 suppositories.

- In asthenic conditions, neurotic and somatoform disorders, with mental, behavioral and postabstinence disorders, in patients with alcohol and drug dependence: 5 days with one suppository daily, then one suppository every 72 hours. The course of 15-20 suppositories.

- To increase physical performance: 1 suppository every other day - 5 suppositories, then one suppository every 72 hours, the course - up to 20 suppositories.

Overdose .

Overdose has not been reported.

Description

Suppositories from white to white with a yellowish shade, torpedo-shaped with no visible blotches on the longitudinal section.

Special directions

To prevent urogenital infection, it is recommended to consider simultaneous treatment of the sexual partner.


Administration during pregnancy and lactation

The drug is contraindicated in pregnancy and during breast-feeding.

Contraindications .

Hypersensitivity to Galavit and other components of the drug, pregnancy and lactation, children under 12 years of age.

Side effects

In rare cases, allergic reactions are possible. If you notice any side effects mentioned in the instructions or if they worsen, or if you notice any other side effects not mentioned in the instructions, please inform your doctor.

Interactions

When concomitant use, it is possible to reduce the course doses of antibiotics. Cases of incompatibility with other drugs have not been reported.



Effect on the ability to drive vehicles and mechanisms: Has not been studied.

Form of production

Rectal suppositories 100 mg. Packed in 5 capsules in a small carton box, 1 or 2 cartons with instructions for use in a carton pack.

Storage conditions

Store at 25°C or less, protected from light.

Keep out of reach of children.

Shelf life


3 years.

Do not use after the expiration date printed on the carton.

Active ingredient

Sodium aminodihydrophthalazindione

Dosage form

rectal suppositories

Administration

Children by prescription

Indications

Gastric and 12 duodenal ulcer, Boils, Herpes, Bronchitis, Otitis, Urinary tract infections, Colds, Periodontitis, Hepatitis, Sore throat, Tonsillitis, Alcoholism, Diarrhea, Oral inflammation