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Linex Forte N7 caps
Linex Forte N7 caps
Product Code: linex-f-n7 SANDOZ

Linex Forte N7 caps

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$11.00
48
Active substance
Lactobacillus acidophillus, Bifidobacterium BB12

Composition
1 capsule contains: Active ingredient: Probio-tech AB Blend 64 powder (Probio-tec® AB Blend 64) - 60,000 mg (powder contains active ingredients: Lactobacillus acidophilus (LA-5) - 13.8 mg and Bifidobacterium animalis subsp. Lactis (BB-12) - 4.2 mg; auxiliary components: anhydrous dextrose - 29.1 mg, microcrystalline cellulose - 6 mg, potato starch 6 mg, magnesium stearate - 0.9 mg). Excipients: Beneo Synergy 1 (Beneo® Synergy 1) - 171.500 mg (powder contains 90-94% inulin and 6-10% oligofructose (dextrose + fructose + sucrose)); magnesium stearate - 3,500 mg. The composition of the capsule body: hypromellose - 33.149 mg, titanium dioxide (E 171) - 0.691 mg. The composition of the capsule cap: hypromellose - 22.080 mg, dye of titanium dioxide (E 171) - 0.240 mg, dye of iron oxide yellow (E 172) - 0.240 mg.

Pharmachologic effect
PHARMACOTHERAPEUTIC GROUP

Eubiotic. ATX Code: A07FA51

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics

Linex® Forte normalizes the intestinal microflora. One capsule of Linex Forte contains lactic acid bacteria (Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. Lactis (BB-12)), each capsule contains 109 colony forming units of live lyophilized lactic acid bacteria. Live lactic acid bacteria are a normal component of the natural intestinal microflora. The main functions of lactic acid bacteria:

protective: synthesis of substances with antibacterial activity;
enzyme-producing: hydrolysis of fiber, proteins, fats, starch, deconjugation of bile acids
synthetic: synthesis of B, C, K vitamins, amino acids, organic acids, etc. Lactic acid bacteria LA-5 and BB-12 inhibit the growth of pathogenic bacteria by:
lower intestinal pH (the result of the ability of LA-5 to synthesize lactic acid and BB-12 to synthesize acetic and succinic acids in addition to lactic acid);
production of metabolites that have a toxic effect against pathogenic bacteria (the formation of H2O2);
the formation of antimicrobial agents, bacteriocins (LA-5 secretes acidocin, a broad-spectrum bacteriocin that inhibits the growth of bacteria and fungi);
competition with pathogenic bacteria for nutrients;
interactions with adhesion receptors, thus preventing the colonization of other potentially pathogenic microorganisms.
Pharmacokinetics

Lactic acid bacteria, such as LA-5 and BB-12, act directly in the gastrointestinal tract, when taken orally, the drug is not subjected to systemic absorption. Standard pharmacokinetic studies are therefore not applicable. The resistance of LA-5 and BB-12 to the effects of gastric juice and bile allows strains to survive in large numbers when passing through the stomach and duodenum. Both strains attach to the intestinal mucosa. Like other microorganisms, they are gradually excreted from the gastrointestinal tract by motility and defecation.

Indications
Treatment and prevention of intestinal dysbiosis. Intestinal dysbiosis is manifested by the following symptoms: diarrhea (diarrhea), dyspepsia (indigestion), constipation, flatulence (bloating), nausea, belching, vomiting, abdominal pain, allergic skin reactions are possible.

Contraindications
- hypersensitivity to the components of the drug;

- hereditary fructose intolerance, sucrose deficiency, isomaltase, or glucose-galactose malabsorption.

CAREFULLY

With caution in diabetes mellitus (simple sugars are included), deficiency of the immune system (for example, HIV infection). Diarrhea in children under 6 years of age must be treated under medical supervision.

Side effects
Side effects when taking lactic acid bacteria are very rare (observed in 1 out of 10,000 people). Hypersensitivity reactions may occur.

Interaction
Undesirable interactions with other drugs have not been noted. With the simultaneous use of antibiotics, the recommended interval between taking the drug (antibiotic) and Linex Forte capsules is 3 hours.

How to take, course of administration and dosage
Linex Forte capsules are preferably taken during or after meals with a small amount of liquid. Adults and adolescents over 12 years: 1 capsule 1-3 times a day. Children from 2 to 12 years: 1 capsule 1-2 times a day. Newborns and children up to 2 years: 1 capsule 1 time per day. Diarrhea in children under 6 years of age must be treated under medical supervision. When prescribing Linex® Forte, children and patients who cannot swallow an entire capsule must be opened, pour the contents into a spoon and mix with a small amount of liquid. The duration of treatment depends on the cause of the development of dysbiosis and the individual characteristics of the body. Linex Forte can be taken until the symptoms of dysbiosis disappear. Do not exceed recommended daily doses of the drug.

Overdose
There are no data on overdose symptoms.

Special instructions
Linex® Forte should not be washed down with hot drinks and taken at the same time as alcohol.

The patient should consult a doctor if, before starting the use of the drug, he has a body temperature above 38 ° C, blood or mucus in the stool, diarrhea lasts more than 2 days and is accompanied by acute abdominal pain, dehydration and weight loss; as well as in the presence of chronic diseases (diabetes mellitus, HIV infection).

In the treatment of diarrhea, it is necessary to compensate for lost fluid and electrolytes.

No special precautions are necessary when disposing of unused Linex Forte.

Pediatric Use

Diarrhea in children under 6 years of age must be treated under medical supervision.

Influence on the ability to drive vehicles and control mechanisms

The drug does not affect the ability to drive vehicles and control mechanisms.

Release form
Opaque capsules, white body - yellow cap. The contents of the capsule: light beige powder with a splash of yellow.