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Nurofen 200mg tabs N20
Nurofen 200mg tabs N20
Product Code: 866

Nurofen 200mg tabs N20

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$6.50
16
Description

Release form, composition and packaging

Coated tablets of white or off-white color, round, biconvex, with black Nurofen" overprinting on one side

on a cross-section of a tablet, the core is white or almost white, the shell is white or almost white.

1 tab.

ibuprofen 200 mg

croscarmellose sodium - 30 mg, sodium lauryl sulfate - 0.5 mg, sodium citrate dihydrate - 43.5 mg, stearic acid - 2 mg, colloidal silicon dioxide - 1 mg.

Shell composition: sodium carmellose - 0.7 mg, talc - 33 mg, acacia gum - 0.6 mg, sucrose - 116.1 mg, titanium dioxide - 1.4 mg, macrogol 6000 - 0.2 mg, black ink [Opakod S-1-277001] (shellac - 28.225%, iron dye black oxide (E172) - 24.65%, propylene glycol - 1.3%, isopropanol * - 0.55%, butanol * - 9.75%, ethanol * - 32.275%, purified water * - 3.25%).

* solvents evaporated after the printing process.

6 pcs.

- blisters (1) - cardboard packs.

6 pcs.

- blisters (2) - cardboard packs.

8 pcs.

- blisters (1) - cardboard packs.

8 pcs.

- blisters (2) - cardboard packs.

10 pieces.

- blisters (1) - cardboard packs.

10 pieces.

- blisters (2) - cardboard packs.

10 pieces.

- blisters (3) - cardboard packs.

12 pcs.

- blisters (1) - cardboard packs.

12 pcs.

- blisters (2) - cardboard packs.

12 pcs.

- blisters (3) - cardboard packs.

12 pcs.

- blisters (4) - cardboard packs.

12 pcs.

- blisters (8) - cardboard packs.

pharmachologic effect

NSAIDs.

Has a fast directed action against pain (analgesic), antipyretic and anti-inflammatory action.

The mechanism of action of ibuprofen, a propionic acid derivative, is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction.

Indiscriminately blocks COX-1 and COX-2, as a result of which it inhibits the synthesis of prostaglandins.

In addition, ibuprofen reversibly inhibits platelet aggregation.

The analgesic effect of the drug lasts up to 8 hours.

Pharmacokinetics

Absorption and distribution Absorption - high, quickly and almost completely absorbed from the gastrointestinal tract. After taking the drug on an empty stomach, Cmax of ibuprofen in blood plasma is reached after 45 minutes. Taking the drug with food can increase the time to reach Cmax up to 1-2 hours. Plasma protein binding is 90%. It slowly penetrates into the joint cavity, remains in the synovial fluid, creating higher concentrations in it than in the blood plasma. In the cerebrospinal fluid, lower concentrations of ibuprofen are found in comparison with blood plasma. In limited studies, ibuprofen has been found in breast milk at very low concentrations. Metabolism and excretion After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. It is metabolized in the liver.It is excreted by the kidneys (unchanged - no more than 1%) and, to a lesser extent, with bile. T1 / 2 - 2 hours

Indications for use

- headache

- migraine

- toothache

- neuralgia

- myalgia

- back pain

- rheumatic pains

- joint pain

- algodismenorrhea

- fever with flu and ARVI.

Contraindications for use

- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (including history)

- erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer and duodenal ulcer, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcerative bleeding)

- a history of bleeding or perforation of gastrointestinal ulcers, provoked by the use of NSAIDs

- severe liver failure or liver disease in the active phase

- renal failure of severe severity (CC < 30 ml / min)

& m

Dosage

200mg

Structure

One film-coated tablet contains the active ingredient - ibuprofen 200 mg

excipients: croscarmellose sodium 30 mg, sodium lauryl sulfate 0.5 mg, sodium citrate dihydrate 43.5 mg, stearic acid 2 mg, colloidal silicon dioxide 1 mg.

shell composition: sodium carmellose 0.7 mg, talc 33 mg, acacia gum 0.6 mg, sucrose 116.1 mg, titanium dioxide 1.4 mg, macrogol 6000 0.2 mg, black ink [Opakod S-1-277001 ] (shellac 28.225%, iron dye black oxide (E172) 24.65%, propylene glycol 1.3%, isopropanol * 0.55%, butanol * 9.75%, ethanol * 32.275%, purified water * 3.25% ).

* Solvents evaporated after the printing process.

Indications

headache

migraine

toothache

neuralgia

myalgia

back pain

rheumatic pains

joint pain

algodismenorrhea

fever with flu and ARVI.

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 3 years

Contraindications

complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (including in history)

erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer and duodenal ulcer, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcerative bleeding)

a history of bleeding or perforation of a gastrointestinal ulcer, provoked by the use of NSAIDs

severe liver failure or active liver disease

renal failure of severe severity (CC < 30 ml / min)

confirmed hyperkalemia

severe heart failure (NYHA class IV)

decompensated heart failure

period after coronary artery bypass grafting

cerebrovascular or other bleeding

hemophilia and other blood clotting disorders (including hypocoagulation)

hemorrhagic diathesis

III trimester of pregnancy

children under 6 years old

fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase deficiency

hypersensitivity to ibuprofen and other components of the drug.

With caution, the drug should be prescribed with the simultaneous use of other NSAIDs a history of a single episode of gastric ulcer and duodenal ulcer and duodenal ulcer or gastrointestinal ulcer bleeding gastritis, enteritis, colitis, Helicobacter pylori infection, ulcerative colitis bronchial asthma or allergic diseases in an exacerbation stage or in history (bronchospasm may develop) systemic lupus erythematosus or mixed connective tissue disease (Sharp's syndrome) - increased risk of aseptic meningitis chickenpox renal failure, incl. with dehydration (CC less than 30-60 ml / min), nephrotic syndrome liver failure, liver cirrhosis with portal hypertension, hyperbilirubinemia arterial hypertension and / or heart failure,cerebrovascular diseases blood diseases of unknown etiology (leukopenia and anemia) severe somatic diseases dyslipidemia / hyperlipidemia diabetes mellitus peripheral arterial disease the simultaneous use of drugs that can increase the risk of ulcers or bleeding, in particular, oral corticosteroids (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel) in the I and II trimesters of pregnancy, during breastfeeding elderly patients, patients under the age of 12 when smoking, frequent alcohol consumption.severe somatic diseases dyslipidemia / hyperlipidemia diabetes mellitus peripheral arterial disease the simultaneous use of drugs that can increase the risk of ulcers or bleeding, in particular, oral corticosteroids (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel) in the I and II trimesters of pregnancy, during breastfeeding elderly patients, patients under the age of 12 when smoking, frequent alcohol consumption.severe somatic diseases dyslipidemia / hyperlipidemia diabetes mellitus peripheral arterial disease the simultaneous use of drugs that can increase the risk of ulcers or bleeding, in particular, oral corticosteroids (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel) in the I and II trimesters of pregnancy, during breastfeeding elderly patients, patients under the age of 12 when smoking, frequent alcohol consumption.which can increase the risk of ulcers or bleeding, in particular, oral corticosteroids (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel) in the I and II trimesters of pregnancy, during breastfeeding elderly patients, patients under the age of 12 when smoking, frequent alcohol consumption.which can increase the risk of ulceration or bleeding, in particular, oral corticosteroids (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel) in the I and II trimesters of pregnancy, during breastfeeding elderly patients, patients under the age of 12 when smoking, frequent alcohol consumption.period of breastfeeding elderly patients, patients under the age of 12 when smoking, frequent alcohol consumption.period of breastfeeding elderly patients, patients under the age of 12 when smoking, frequent alcohol consumption.

INN / Active ingredient

Ibuprofen

Specifications

Category

Pain relievers

,

Migraine

,

Pain and fever

Scope of the drug

General

Release form

Tablet

Manufacturer country

Great Britain

Package quantity, pcs

twenty

Vacation conditions

Without recipe

Brand name

Nurofen

The amount of the dosage form in the primary package

10 pieces.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

NSAIDs

Anatomical and therapeutic characteristics

M01AE01 Ibuprofen

Dosage form

Film-coated tablets

Expiration date in days

1095

Package weight, g

twenty

Mode of application

:

For oral administration. Patients with hypersensitivity of the stomach are advised to take the drug with meals. For short term use only. Read the instructions carefully before taking the drug. Adults and children over 12 years old: by mouth 1 tablet (200 mg) up to 3-4 times a day. The tablets should be taken with water. To achieve a faster therapeutic effect in adults, the dose can be increased to 2 tablets (400 mg) up to 3 times a day. Children from 6 to 12 years old: 1 tablet (200 mg) up to 3-4 times a day the drug can be taken only if the child's body weight is more than 20 kg. The interval between pills should be at least 6 hours. The maximum daily dose for adults is 1200 mg (6 tablets). Maximum daily dose for children from 6 to 18 years old: 800 mg (4 tablets).If, after taking the drug for 2-3 days, the symptoms persist or worsen, you must stop treatment and consult a doctor.

Information on technical characteristics, delivery set, country of manufacture "