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Advantan ointment 0.1%, 50 g
Advantan ointment 0.1%, 50 g
Product Code: 545

Advantan ointment 0.1%, 50 g

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Release form

Ointment 0.1%

Pharmacological action

corticosteroids for external use, is a non-halogenated synthetic steroid. When used externally, Advantan suppresses inflammatory and allergic skin reactions, as well as reactions associated with increased proliferation, which leads to a decrease in objective symptoms (erythema, edema, lichenification) and subjective sensations (itching, irritation, pain).

When using methylprednisolone aceponate externally, the systemic effect is minimally expressed in both humans and animals. After repeated application of Advantan to large surfaces (40-60% of the skin surface), as well as when applied under an occlusive dressing, there is no adrenal gland dysfunction: the level of cortisol in the blood plasma and its circadian rhythm remain within normal limits, the level of cortisol in the daily urine does not decrease going on.

In clinical trials with the use of Advantan in the form of an ointment, cream, oily ointment or emulsion for up to 12 weeks in adults and up to 4 weeks in children (including young children), no development of atrophy of the skin, telangiectasia, striae and acne-like rashes.

Methylprednisolone aceponate (especially its main metabolite, 6β-methylprednisolone-17-propionate) binds to intracellular glucocorticoid receptors. The steroid-receptor complex binds to certain sections of DNA, thus causing a series of biological effects.

In particular, the binding of the steroid-receptor complex to DNA leads to the induction of macrocortin synthesis. Macrocortin inhibits the release of arachidonic acid and, thus, the formation of an inflammatory mediator such as prostaglandins and leukotrienes.

Inhibition of GCS synthesis of vasodilating prostaglandins and potentiation of the vasoconstrictor action of adrenaline leads to a vasoconstrictor effect.


Inflammatory skin diseases that are sensitive to topical corticosteroids therapy:

- atopic dermatitis, neurodermatitis, childhood eczema

- true eczema

- microbial eczema

- occupational eczema

- dyshrotic contact dermatitis - dyshrotic dermatitis dermatitis.


- skin tuberculosis and skin manifestations of syphilis in the area of ​​application of the drug

- viral skin lesions in the area of ​​application of the drug (for example, with chicken pox, herpes zoster)

- rosacea, perioral dermatitis in the area of ​​application of the drug

vaccination - children under 4 months of age

- hypersensitivity to the components of the drug.

Use during pregnancy and lactation

If you need to use the drug Advantan during pregnancy and lactation, you should carefully weigh the expected benefits of therapy for the mother and the potential risk to the fetus or infant.

In this category of patients, it is not recommended to use the drug for a long time on extensive skin surfaces.

Nursing mothers should not apply the drug to the mammary glands.

Special instructions

In the presence of bacterial dermatoses and / or dermatomycoses, in addition to Advantan therapy, specific antibacterial or antifungal treatment is necessary.

Avoid contact with eyes.

As with systemic corticosteroids, topical corticosteroids may cause glaucoma (for example, after high doses or for very long periods, using occlusive dressings or applying to the skin around the eyes).

Does not affect the ability to drive vehicles and work with mechanisms.

Composition of

1 g of ointment contains:

methylprednisolone aceponate 1 mg.


white soft paraffin - 350 mg,

liquid paraffin - 239 mg, white

beeswax white - 40 mg,

emulsifier Dehimuls E - 70 mg, purified water

- 300 mg.

Dosage and administration

The drug is applied 1 time / day with a thin layer on the affected skin.

The continuous daily use of Advantan in the form of ointment is for adults no more than 12 weeks, for children - no more than 4 weeks.

Ointment is prescribed for the treatment of skin diseases that are not accompanied by weeping and in the presence of infiltration, in which a dosage form with a balanced ratio of fat and water is necessary. Advantan ointment makes the skin slightly oily without delaying heat and moisture.

Side effects

The drug is usually well tolerated.

Very rarely (in less than 0.01% of cases) local reactions such as itching, burning, erythema, and the formation of a vesicular rash can be observed.

If the drug is used for more than 4 weeks and / or on an area of ​​10% or more of the body surface, the following reactions may occur: skin atrophy, telangiectasia, striae, acneform skin changes, systemic effects due to corticosteroid absorption.

In clinical trials, none of the above side effects were observed with Advantan before 12 weeks in adults and up to 4 weeks in children.

In rare cases (0.01-0.1%), folliculitis, hypertrichosis, perioral dermatitis, skin depigmentation, allergic reactions to one of the components of the drug can be observed.

Drug Interactions

Drug Interactions Advantan not described.


In the study of the acute toxicity of methylprednisolone aceponate, no risk of acute intoxication was observed in the case of excessive single external use (application of the drug to a large area under conditions favorable for absorption) or absorption.

Symptoms: Skin atrophy (thinning of the skin, telangiectasia, stretch marks) can develop with excessively long and / or intensive topical application of ACS.

Treatment: Withdrawal.

Storage Conditions

The product should be stored at a temperature not exceeding 25 РC.

Keep out of the reach and sight of children.

Shelf life

3 years.

Deystvuyushtee substance

methylprednisolone aceponate

Conditions for dispensing from pharmacies

Without a prescription

dosage form