Pharmacological action
Differin - comedonolytic, anti-inflammatory.
Pharmacodynamics
Adapalene is a metabolite of retinoid, has comedonolytic and anti-inflammatory activity, normalizes the processes of keratinization and epidermal differentiation. The mechanism of action of adapalene is based on interaction with specific γ-receptors of epidermal skin cells.
As a result of the action of adapalene, in particular, there is a decrease in the "adherence" of epithelial cells in the mouth of the sebaceous-hair follicle and reduce the prerequisites for the formation of microcomedones.
Adapalene has anti-inflammatory effect in vivo and in vitro, acting on inflammation factors by inhibiting the migration of leukocytes in the focus of inflammation and metabolism of arachidonic acid.
Pharmacokinetics
Absorption of adapalene through the skin is very low (about 4% of the administered dose). Excretion from the body occurs mainly through the bile.
Indications
Acne.
Use in pregnancy and lactation
Differin is contraindicated in pregnancy and lactation
Contraindications
Hypersensitivity to one of the ingredients of the drug.
With caution: Dermatitis, eczema.
Side effects
Skin irritation (treatment should be suspended until the disappearance of skin irritation or reduce the frequency of use).
Interaction
Since the drug does not interact with oxygen and is not destroyed by light, it can be used with other topical and systemic acne medications such as clindamycin phosphate or benzoyl peroxide.
How to take, course of administration and dosage
Externally. With a light touch, apply the gel or cream evenly to the affected area once daily before bedtime on clean, dry skin, avoiding contact with the eyes and lips.
Therapeutic effect develops after 4-8 weeks of treatment, persistent improvement after 3 months of treatment.
In some cases, due to short-term skin irritation, the number of applications may be reduced or treatment may be suspended until the signs of irritation disappear.
Repeated treatment is possible after consultation with a doctor.
Special instructions
Contact of gel or cream with eyes, lips and mucous membranes should be avoided.
In case of accidental contact of the drug with the mucous membranes of the eyes, mouth or nose, rinse thoroughly with warm water.
Avoid direct sunlight, as slight skin irritation may occur. Treatment can be continued if sun exposure is minimized (use of sunglasses and hats).
The concomitant use of cosmetics with a drying or irritating effect on the skin (e.g. perfumes or alcohol-containing products) is not recommended.
Adapalene, applied to the skin in the evening, can be combined with preparations for the treatment of acne, applied in the morning.
Form of release
gel for external use
Storage conditions
At a temperature not exceeding 25 °C
Differin - comedonolytic, anti-inflammatory.
Pharmacodynamics
Adapalene is a metabolite of retinoid, has comedonolytic and anti-inflammatory activity, normalizes the processes of keratinization and epidermal differentiation. The mechanism of action of adapalene is based on interaction with specific γ-receptors of epidermal skin cells.
As a result of the action of adapalene, in particular, there is a decrease in the "adherence" of epithelial cells in the mouth of the sebaceous-hair follicle and reduce the prerequisites for the formation of microcomedones.
Adapalene has anti-inflammatory effect in vivo and in vitro, acting on inflammation factors by inhibiting the migration of leukocytes in the focus of inflammation and metabolism of arachidonic acid.
Pharmacokinetics
Absorption of adapalene through the skin is very low (about 4% of the administered dose). Excretion from the body occurs mainly through the bile.
Indications
Acne.
Use in pregnancy and lactation
Differin is contraindicated in pregnancy and lactation
Contraindications
Hypersensitivity to one of the ingredients of the drug.
With caution: Dermatitis, eczema.
Side effects
Skin irritation (treatment should be suspended until the disappearance of skin irritation or reduce the frequency of use).
Interaction
Since the drug does not interact with oxygen and is not destroyed by light, it can be used with other topical and systemic acne medications such as clindamycin phosphate or benzoyl peroxide.
How to take, course of administration and dosage
Externally. With a light touch, apply the gel or cream evenly to the affected area once daily before bedtime on clean, dry skin, avoiding contact with the eyes and lips.
Therapeutic effect develops after 4-8 weeks of treatment, persistent improvement after 3 months of treatment.
In some cases, due to short-term skin irritation, the number of applications may be reduced or treatment may be suspended until the signs of irritation disappear.
Repeated treatment is possible after consultation with a doctor.
Special instructions
Contact of gel or cream with eyes, lips and mucous membranes should be avoided.
In case of accidental contact of the drug with the mucous membranes of the eyes, mouth or nose, rinse thoroughly with warm water.
Avoid direct sunlight, as slight skin irritation may occur. Treatment can be continued if sun exposure is minimized (use of sunglasses and hats).
The concomitant use of cosmetics with a drying or irritating effect on the skin (e.g. perfumes or alcohol-containing products) is not recommended.
Adapalene, applied to the skin in the evening, can be combined with preparations for the treatment of acne, applied in the morning.
Form of release
gel for external use
Storage conditions
At a temperature not exceeding 25 °C
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