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Sorbifer Durules N50
Sorbifer Durules N50
Product Code: sorbifer-50 EGIS

Sorbifer Durules N50

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$19.00 $15.20
1


Composition
Each coated tablet contains:


Divalent iron sulfate in an amount equivalent to 100 mg of Fe2+ and 60 mg of ascorbic acid,


as well as:

  • magnesium stearate,
  • povidone K-25,
  • polyethylene powder,
  • carbomer 934 R.


The shell contains:

  • hypromellose,
  • macrogol 6000,
  • titanium dioxide,
  • iron oxide yellow,
  • solid paraffin.


Pharmacological action
Pharmacotherapeutic group:

iron drug

ATX code:

B03A A07

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics

Iron is an irreplaceable component of the body necessary for formation of hemoglobin and oxidation processes in living tissues. The preparation is used for elimination of iron deficiency. Durules technology provides gradual release of the active ingredient (iron ions) over a long period of time.

Plastic matrix of Sorbifer Durules tablets is completely inert in digestive juice, but completely disintegrates under the influence of intestinal peristalsis, when the active ingredient is completely released.

Pharmacokinetics

Durules is a technology that provides a gradual release of the active ingredient (iron ions), a uniform intake of the drug. Taking 100 mg twice a day provides 30% more iron absorption from Sorbifer Durules compared to conventional iron preparations.

Absorption and bioavailability of iron are high. Iron is absorbed mainly in the 12 duodenum and proximal part of the jejunum. Binding to plasma proteins is 90% and more. It is deposited in the form of ferritin or hemosiderin in hepatocytes and cells of the system of phagocytic macrophages, a minor amount is deposited in the form of myoglobia in muscles. The elimination half-life is 6 hours.
Indications

    Iron deficiency anemia.
    Iron deficiency.
    Prophylactic use in pregnancy, lactation and blood donors.

Contraindications .

    Hypersensitivity to the drug components.
    Stenosis of the esophagus and / or obstructive changes in the digestive tract.
    Increased iron content in the body (hemosiderosis, hemochromatosis).
    Impaired iron utilization (lead anemia, sideroblast anemia, hemolytic anemia).
    Childhood under 12 years of age (because of the lack of clinical data).

Caution: peptic ulcer and 12 duodenal ulcer, inflammatory bowel disease (enteritis, diverticulitis, ulcerative colitis, Crohn's disease).

Side effects
Nausea, vomiting, abdominal pain, diarrhea, constipation.

The frequency of gastrointestinal side effects may increase with increasing doses from 100 to 400 mg. The following side effects may be observed rarely (<1/100): esophageal ulceration, esophageal stenosis, allergic reactions (itching, rash), skin hyperthermia, headache, dizziness, weakness.
Interaction
Durules may reduce absorption of concomitantly used enoxacin, clodronate, grepafloxacin, levodopa, levofloxacin, methyldopa, penicillamine, tetracyclines and thyroid hormones.

Simultaneous use of Sorbifer Durules and antacids containing aluminum hydroxide and magnesium carbonate may reduce iron absorption.

The maximum possible time interval between taking Sorbifer Durules and any of these drugs should be as long as possible.

The recommended minimum interval between doses is 2 hours, except when taking tetracyclines, when the minimum interval should be 3 hours. Sorbifer Durules should not be combined with the following drugs: ciprofloxacin, doxycycline, norfloxacin and ofloxacin.

How to take, the course of treatment and dosage
The coated tablets are taken orally.
They should not be divided or chewed.
The tablet should be swallowed whole and drunk with at least half a glass of liquid. Adults and adolescents:

1 tablet 1-2 times a day. If necessary, patients with iron deficiency anemia, the dose can be increased to 3-4 tablets a day for two doses (morning and evening) for 3-4 months (to replenish the iron depot in the body).

In pregnancy and lactation:

Prevention: 1 tablet a day.

Therapeutic doses: 1 tablet 2 times a day (morning and evening). Treatment should be continued until optimal hemoglobin level is achieved. For further depot replenishment it may be necessary to continue treatment for 2 months.
Overdose
Symptoms: abdominal pain, vomiting and diarrhea with blood admixture, fatigue or weakness, hyperthermia, parasthesias, pale skin, cold clammy sweat, acidosis, weak pulse, decreased blood pressure, palpitation.

In severe overdose signs of peripheral circulatory collapse, coagulopathy, hyperthermia, hypoglycemia, liver damage, renal failure, muscle cramps and coma may appear after 6-12 hours.

Treatment: In case of overdose consult a physician immediately. Necessary gastric lavage, ingestion of raw egg, milk (to bind iron ions in the gastrointestinal tract); administer deferoxamine. Symptomatic therapy.
Special directions

Darkening of stools is possible, which has no clinical significance.
Pregnancy and lactation
Sorbifer Durules may be used during pregnancy and lactation.

Form of release

Coated tablets Sorbifer Durules

Conditions of storage.
In dry place, protected from light, at a temperature not exceeding 20 ° C.
Shelf life
3 years.
Active substance
Iron sulfate, ascorbic acid


Darkening of stools is possible, which has no clinical significance.
Pregnancy and lactation
Sorbifer Durules may be used during pregnancy and lactation.

Form of release

Coated tablets Sorbifer Durules

Conditions of storage.
In dry place, protected from light, at a temperature not exceeding 20 ° C.
Shelf life
3 years.
Active substance
Iron sulfate, ascorbic acid