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Carsil, Silymarin 35 mg N80
Carsil, Silymarin 35 mg N80
Product Code: Karsil-80

Carsil, Silymarin 35 mg N80

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thistle fruit dry extract (equivalent silymarin) 35 mg

Excipients: lactose monohydrate, wheat starch, povidone (kolidon 25), microcrystalline cellulose, magnesium stearate, talc, dextrose monohydrate, sorbitol, sodium hydrogen carbonate.

shell composition: tsellatsefat, diethyl phthalate, sucrose, gum acacia, gelatin, talc, titanium dioxide, Macrogol (PEG 6000), Brown dye Opalyuks (sucrose, iron oxide red, black iron oxide, methyl and propyl parahydroxybenzoate, purified water), glycerol.
pharmachologic effect
Hepatoprotectors. It contains dry extract of milk thistle (silymarin equivalent), which is a mixture of 4 isomers flavonolignans: silibinin, iso-silibinin, silydianin and silychristin. The mechanism of action of the drug is not clear. It is known that the action associated with hepatoprotective silymarin competitively reacting with the toxins for the respective receptors on the membrane of hepatocytes; This is due to membrane stabilizing action.

It affects the metabolism and other cellular processes by inhibiting 5-lipoxygenase pathway (in particular, leukotriene B4) binding to reactive oxygen free radicals. It speeds up the regenerative processes by stimulating the synthesis of proteins (structural and functional) and phospholipids in hepatocytes affected.

Flavonoids, which belongs to silymarin, also have antioxidant effects, improve microcirculation. Clinically, these effects are expressed in the improvement of subjective symptoms and normalization of hepatic function (transaminases, level? Globulin, bilirubin). It improves the general condition of patients, reduce the number of complains related to the gastrointestinal tract. In patients with reduced assimilation of food-related liver disease, increased appetite and weight gain occurs.


Absorption and distribution

After oral silymarin is slowly absorbed from the gastrointestinal tract. Treated enterohepatic circulation. Not accumulates in the body.

In the study of silibinin, 14C-labeled, the highest concentrations found in the liver and very minor amounts - in the kidneys, lungs, heart and other organs.

Metabolism and excretion

It is metabolized in the liver by conjugation. T1 / 2 -. 6 hours is derived predominantly (80%) in the bile in the form of glucuronides and sulfates, and to a minor extent (about 5%) in urine.
Side effects
From the digestive system: rarely - nausea, dyspepsia, diarrhea.

Allergic reactions: in some cases - pruritus, rash.

Other: rarely - worsening of existing vestibular disorders, in some cases - alopecia.

Karsil well tolerated. Side effects are rare, are transient in nature and disappear after the abolition of the drug.

Ыale Properties
No prescription

Special conditions
In applying the drug may be a manifestation estrogenic action of silymarin. Therefore patients with hormonal disorders (endometriosis, uterine fibroids, breast carcinoma, ovary, uterus, prostate) drug prescribed with caution.

In preparation Karsil as an adjunct contains wheat starch, which may pose a risk for patients with celiac disease (gluten enteropathy).

Also, as an auxiliary component in a formulation contained glycerol, in high doses which can cause headaches or have an irritant effect on the gastric mucosa.

- Toxic liver damage;

- Condition after suffering a hepatitis;

- Chronic hepatitis non-viral etiology;

- Cirrhosis of the liver (in the complex therapy);

- Hepatic steatosis (alcoholic and non-alcoholic);

- For the prevention of chronic administration of drugs, alcohol, chronic intoxication (including professional).

- Children up to age 12 years;

- Hypersensitivity to the drug.
Tags: Carsil, Silymarin,